A Guide to 2C-B-FLY: Ann Shulgin’s Favourite Molecule

It’s also dangerous to combine FLY with any type of MAOi-containing substance, such as ayahuasca or SSRIs. It usually lasts anywhere from six to 12 hours, with most moderate doses lasting around eight. I’ll admit, I’m not the most educated when it comes to obscure psychedelic research chemicals, so I assumed they were the same thing, but as I continued to do more research, I quickly realized that I was wrong.

Little is known about how the totality of its effects are produced, 2C-B-FLY’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation. The hallucinogenic effect of 2C-B-FLY is mediated by its partial agonistic activity at the 5-HT2A serotonin receptor, but 2C-B-FLY also has a high binding affinity for the 5-HT2B and 5-HT2C serotonin receptor.

Dosage

• It has been subject of little formal study, but its appearance as a designer drug has led the DEA to release analytical results for 2C-B-FLY and several related compounds.
• In the United States, 2C-B-FLY isn’t directly mentioned, which would make it an unscheduled substance.
• Let the drug completely dissolve into the water.Use a 1 ml syringe, put the liquid into it and plug the substance into your a#s.You need to put the syringe deep enough but not too deep either.
• In theory, dihydrodifuran analogues of any of the 2Cx / DOx family of drugs could be made, and would be expected to show similar activity to the parent compound.
• Even subtle changes in the dose with 2C-B can change the experience from euphoric and empathogenic to powerfully psychedelic and dissociative.

It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline. The mechanism of action is not fully known, although serotonin receptor binding activity is thought to be principally involved. The diversity of chemicals that have psychedelic effects is staggering. Scientists have been taking known psychedelic compounds, like LSD or mescaline, and modifying them ever so slightly to search for new hallucinogenic derivatives. In theory, dihydro-difuran analogs of any of the 2Cx / DOx family of drugs could be made, and would be expected to show similar activity to the parent compounds, 2-CB, DOB, DOM, etc.

In the same way that 2C-B-FLY is the dihydro-difuran analog of 2C-B, the 8-iodo equivalent, “2C-I-FLY,” would be the dihydro-difuran analogue of 2C-I, and the 8-methyl equivalent, “2C-D-FLY,” would be the dihydro-difuran analogue of 2C-D. 2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound’s non-rigid counterpart 2C-B.

• Substituted phenethylamines are a chemical class of organic compounds that are based upon the phenethylamine structure, a phenyl ring bound to an amino (NH2) group through an ethyl chain.
• In August 2007, 2C-B, along with many other psychologically active substances,66 was added to Ley 20.000, known as the Ley de Drogas es.
• However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
• However, none of these other FLY compounds are as popular in the research chemical space as 2C-B-FLY.
• The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact toxic dose is unknown.
• 2C-B-FLY is a derivative of the 2C-x family of psychedelic phenethylamines, specifically 2C-B, of which it significantly differs from in terms of its potency, metabolism, and potential toxicity.

But it is advised to avoid combinin with other empathogens – (MDMA, 6-APB, MDA, 5-MAPB, 3-MMC), the 2C-B-FLY is suspected to act as an MAOI, and it is thus necessary to avoid any mixture with molecules releasing serotonin. Surprisingly, 2C-B-FLY is very similar to molecules like MDMA or 5-MAPB. It has a capacity empathogenic well with him which does not have the same mechanism of action, because weaker than the molecules releasing serotonin.

Mescaline

Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history. Tolerance to the effects of 2C-B is not built almost immediately after ingestion. Members of this class include psychedelics such as 2C-B, 2C-C, 2C-I, and more.

You can microdose with 2C-B-Fly but drugs like LSD, psilocybin, and ibogaine are more suited for this. Keep your powder or pills in a cold dark place, preferably with no air.If you don’t do this, 2C-B-Fly will lose potency within a few weeks or months.When you store the substance well, it will last for years or even decades. 2C-B-Fly will stay in your oral fluid for hours.With that said, the substance is extremely hard to detect and standard drug tests are not capable of that.

Is 2C-B-FLY Safe?

With that said, it shares the most overlap with 2C-B, mescaline, and MDMA. One of the components that make this psychedelic so enticing is that it doesn’t have a debilitating effect on one’s cognitive abilities. Most people can remain entirely coherent without being inhibited like other psychedelics.

Analogues and derivatives

The effects of 2C-B-FLY are dose-dependent — which means the experience is going to be very different if you take a low dose compared to a high dose. There are dozens of mescaline-derived psychedelics, but there’s something about this one in particular that makes it stand out. You’ll begin to experience effects about minutes after taking 2C-B-FLY, and the effects usually last between six and twelve hours.

2C-B-FLY is a derivative of the 2C-x family of psychedelic phenethylamines, specifically 2C-B, of which it significantly differs from in terms of its potency, metabolism, and potential toxicity. Not a lot of academic research has been done on FLY, so, its effects are highly subjective and based on reading through trip reports that can be found online. FLY is reported to give users a significant body high, strong visual effects that morph into different shapes and sizes, and deep internal hallucinations. Its profile is often described as possessing features similar to 2C-B, mescaline, and MDA.

Safety checklist

I have several hundred psychedelic trips behind me, including nearly fifty trips with this molecule. It is not about your age, it is about how mature you are.Teenagers (and younger) generally aren’t responsible enough to take psychedelics but it 2c b fly isn’t always the case.If you are under the age of 21, your brain is evolving at a rapid rate on its own. This means that when you take psychedelics, there is more potential for growth but the risks are also higher.

Many psychonauts recommend starting with a light dose but this isn’t necessarily the best way to go.If you start at lower doses, your ego will learn how to control the psychedelic states. Because of that, it’ll be harder to let go once you move to higher doses and this can easily lead to bad trips.You will also not get as many benefits from the drug as if you were to start with higher doses. It’s been shown that mystical experiences can deeply change your identity and the higher the dose you take, the more intense they will be. Do not, however, start with a strong dose if you don’t have a trip sitter nearby.High doses can easily cause you to reach a breakthrough where you lose sense of the physical world. There are people who can take relatively high doses and feel nothing. Reports have characterized its effects profile as possessing features of 2C-B, mescaline and MDA, with a duration of 6–8 hours (or up to 12 hours in larger doses).

-I: An Obscure, But Powerful Research Chemical

Users have reported experiencing hypertension, hyperthermia and tachycardia at higher doses.22 As such, those with pre-existing heart conditions should avoid using 2C-B, and users monitor their temperature and heart-rate and respond accordingly. It is highly advised to use harm reduction practices if using this substance. Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect. 2C-B-FLY is currently illegal in most parts of the world, and this is unlikely to change unless the general sentiment on psychedelic substances is changed on a federal level. This psychedelic is particularly interesting as a recreational substance for its affinity for creating a positive, energized experience.

A psychoactive dose of 2C-B-FLY is roughly 20 mg, while the psychoactive dose of pure mescaline is closer to 200 mg. LSD, magic mushrooms, and other psychedelics don’t often share this same sentiment. Psychoactive doses make it very difficult to perform normal activities, let alone interact with other people. 2C-B-Fly is a molecule allowing psychedelic exploration while being relatively soft and easy to control.